Androgen Receptor Promotes Sex-Independent Angiogenesis in Response to Ischemia and Is Required for Activation of Vascular Endothelial Growth Factor Receptor Signaling
Author(s) -
Sumiko Yoshida,
Kenichi Aihara,
Yasumasa Ikeda,
Yuka Sumitomo-Ueda,
Ryoko Uemoto,
Kazue Ishikawa,
Takayuki Ise,
Shusuke Yagi,
Takashi Iwase,
Yasuhiro Mouri,
Matomo Sakari,
Takahiro Μatsumoto,
Kenichi Takeyama,
Masashi Akaike,
Mitsuru Matsumoto,
Masataka Sata,
Kenneth Walsh,
Shigeaki Kato,
Toshio Matsumoto
Publication year - 2013
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.113.001533
Subject(s) - angiogenesis , kinase insert domain receptor , endocrinology , protein kinase b , vascular endothelial growth factor , androgen receptor , medicine , vascular endothelial growth factor a , signal transduction , cancer research , biology , microbiology and biotechnology , prostate cancer , cancer , vegf receptors
Hypoandrogenemia is associated with an increased risk of ischemic diseases. Because actions of androgens are exerted through androgen receptor (AR) activation, we studied hind-limb ischemia in AR knockout mice to elucidate the role of AR in response to ischemia.
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