Pivotal Role of Rho-Associated Kinase 2 in Generating the Intrinsic Circadian Rhythm of Vascular Contractility | Zendy

Toshiro Saito | Zendy; Mayumi Hirano | Zendy; Tomomi Ide | Zendy; Toshihiro Ichiki | Zendy; Noriyuki Koibuchi | Zendy; Kenji Sunagawa | Zendy; Katsuya Hirano | Zendy

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Pivotal Role of Rho-Associated Kinase 2 in Generating the Intrinsic Circadian Rhythm of Vascular Contractility

Author(s) -

Toshiro Saito,

Mayumi Hirano,

Tomomi Ide,

Toshihiro Ichiki,

Noriyuki Koibuchi,

Kenji Sunagawa,

Katsuya Hirano

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.135608

Subject(s) - zeitgeber , circadian rhythm , rock2 , medicine , endocrinology , circadian clock , myosin light chain kinase , biology , contractility , clock , rho associated protein kinase , myosin , microbiology and biotechnology , phosphorylation

The circadian variation in the incidence of cardiovascular events may be attributable to the circadian changes in vascular contractility. The circadian rhythm of vascular contractility is determined by the interplay between the central and peripheral clocks. However, the molecular mechanism of the vascular intrinsic clock that generates the circadian rhythm of vascular contractility still remains largely unknown.

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