Open AccessEffective Treatment of Edema and Endothelial Barrier Dysfunction With Imatinib
Author(s) -
Jurjan Aman,
Jan van Bezu,
Amin Damanafshan,
Stephan Huveneers,
Etto C. Eringa,
Steven M. Vogel,
A. B. Johan Groeneveld,
Anton Vonk Noordegraaf,
Victor W.M. van Hinsbergh,
Geerten P. van Nieuw Amerongen
Publication year - 2012
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.112.134304
Subject(s) - medicine , endothelial dysfunction , imatinib , endothelium , pulmonary edema , barrier function , vascular endothelial growth factor b , endothelial stem cell , vascular permeability , tyrosine kinase , tyrosine kinase inhibitor , vascular endothelial growth factor , imatinib mesylate , pharmacology , cancer research , vascular endothelial growth factor a , lung , microbiology and biotechnology , biology , receptor , in vitro , biochemistry , myeloid leukemia , cancer , vegf receptors
Tissue edema and endothelial barrier dysfunction as observed in sepsis and acute lung injury carry high morbidity and mortality, but currently lack specific therapy. In a recent case report, we described fast resolution of pulmonary edema on treatment with the tyrosine kinase inhibitor imatinib through an unknown mechanism. Here, we explored the effect of imatinib on endothelial barrier dysfunction and edema formation.
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