Enhanced Effect of Combining Human Cardiac Stem Cells and Bone Marrow Mesenchymal Stem Cells to Reduce Infarct Size and to Restore Cardiac Function After Myocardial Infarction | Zendy

Adam Williams | Zendy; Konstantinos E. Hatzistergos | Zendy; Benjamin Addicott | Zendy; Fred McCall | Zendy; Decio Carvalho | Zendy; Viky Y. Suncion | Zendy; Azorides R. Morales | Zendy; Jose Da Silva | Zendy; Mark A. Sussman | Zendy; Alan W. Heldman | Zendy; Joshua M. Hare | Zendy

Open Access

Enhanced Effect of Combining Human Cardiac Stem Cells and Bone Marrow Mesenchymal Stem Cells to Reduce Infarct Size and to Restore Cardiac Function After Myocardial Infarction

Author(s) -

Adam Williams,

Konstantinos E. Hatzistergos,

Benjamin Addicott,

Fred McCall,

Decio Carvalho,

Viky Y. Suncion,

Azorides R. Morales,

Jose Da Silva,

Mark A. Sussman,

Alan W. Heldman,

Joshua M. Hare

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.131110

Subject(s) - medicine , ejection fraction , mesenchymal stem cell , stem cell therapy , myocardial infarction , cardiology , contractility , cell therapy , preload , stem cell , cardiac function curve , pathology , hemodynamics , heart failure , biology , genetics

Because mesenchymal stem cells (MSCs) induce proliferation and differentiation of c-kit(+) cardiac stem cells (CSCs) in vivo and in vitro, we hypothesized that combining human (h) MSCs with c-kit(+) hCSCs produces greater infarct size reduction compared with either cell administered alone after myocardial infarction (MI).

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