Renal Sympathetic Denervation for Treatment of Drug-Resistant Hypertension | Zendy

Murray Esler | Zendy; Henry Krum | Zendy; Markus P. Schlaich | Zendy; Roland E. Schmieder | Zendy; Michael Böhm | Zendy; Paul A. Sobotka | Zendy

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Renal Sympathetic Denervation for Treatment of Drug-Resistant Hypertension

Author(s) -

Murray Esler,

Henry Krum,

Markus P. Schlaich,

Roland E. Schmieder,

Michael Böhm,

Paul A. Sobotka

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.130880

Subject(s) - medicine , denervation , blood pressure , renal sympathetic denervation , confidence interval , crossover study , renal artery , catheter , cardiology , anesthesia , sympathectomy , heart rate , surgery , kidney , resistant hypertension , placebo , pathology , alternative medicine

Renal sympathetic nerve activation contributes to the pathogenesis of hypertension. Symplicity HTN-2, a multicenter, randomized trial, demonstrated that catheter-based renal denervation produced significant blood pressure lowering in treatment-resistant patients at 6 months after the procedure compared with control, medication-only patients. Longer-term follow-up, including 6-month crossover results, is now presented.

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