Protein Kinase C-β Contributes to Impaired Endothelial Insulin Signaling in Humans With Diabetes Mellitus | Zendy

Corey E. Tabit | Zendy; Sherene M. Shenouda | Zendy; Monica Holbrook | Zendy; Jessica L. Fetterman | Zendy; Soroosh Kiani | Zendy; Alissa A. Frame | Zendy; Matthew A. Kluge | Zendy; Aaron Held | Zendy; Mustali M. Dohadwala | Zendy; Noyan Gokce | Zendy; Melissa G. Farb | Zendy; James L. Rosenzweig | Zendy; Neil B. Ruderman | Zendy; Joseph A. Vita | Zendy; Naomi M. Hamburg | Zendy

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Protein Kinase C-β Contributes to Impaired Endothelial Insulin Signaling in Humans With Diabetes Mellitus

Author(s) -

Corey E. Tabit,

Sherene M. Shenouda,

Monica Holbrook,

Jessica L. Fetterman,

Soroosh Kiani,

Alissa A. Frame,

Matthew A. Kluge,

Aaron Held,

Mustali M. Dohadwala,

Noyan Gokce,

Melissa G. Farb,

James L. Rosenzweig,

Neil B. Ruderman,

Joseph A. Vita,

Naomi M. Hamburg

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.127514

Subject(s) - medicine , endocrinology , enos , diabetes mellitus , insulin resistance , endothelial dysfunction , insulin , protein kinase c , endothelium , type 2 diabetes mellitus , nitric oxide , phosphorylation , nitric oxide synthase , biology , microbiology and biotechnology

Abnormal endothelial function promotes atherosclerotic vascular disease in diabetes. Experimental studies indicate that disruption of endothelial insulin signaling, through the activity of protein kinase C-β (PKCβ) and nuclear factor κB, reduces nitric oxide availability. We sought to establish whether similar mechanisms operate in the endothelium in human diabetes mellitus.

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