Vascular Endothelial Growth Factor-Angiopoietin Chimera With Improved Properties for Therapeutic Angiogenesis | Zendy

Andrey Anisimov | Zendy; Denis Tvorogov | Zendy; Annamari Alitalo | Zendy; VeliMatti Leppänen | Zendy; Yuri An | Zendy; Eun Chun Han | Zendy; Fabrizio Orsenigo | Zendy; Emília Ilona Gaál | Zendy; Tanja Holopainen | Zendy; Young Jun Koh | Zendy; Tuomas Tammela | Zendy; Petra Korpisalo | Zendy; Salla Keskitalo | Zendy; Michael Jeltsch | Zendy; Seppo YläHerttuala | Zendy; Elisabetta Dejana | Zendy; Gou Young Koh | Zendy; Chulhee Choi | Zendy; Pipsa Saharinen | Zendy; Kari Alitalo | Zendy

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Vascular Endothelial Growth Factor-Angiopoietin Chimera With Improved Properties for Therapeutic Angiogenesis

Author(s) -

Andrey Anisimov,

Denis Tvorogov,

Annamari Alitalo,

VeliMatti Leppänen,

Yuri An,

Eun Chun Han,

Fabrizio Orsenigo,

Emília Ilona Gaál,

Tanja Holopainen,

Young Jun Koh,

Tuomas Tammela,

Petra Korpisalo,

Salla Keskitalo,

Michael Jeltsch,

Seppo YläHerttuala,

Elisabetta Dejana,

Gou Young Koh,

Chulhee Choi,

Pipsa Saharinen,

Kari Alitalo

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.127472

Subject(s) - angiogenesis , angiopoietin receptor , vascular endothelial growth factor , therapeutic angiogenesis , microbiology and biotechnology , receptor , kinase insert domain receptor , medicine , s1pr1 , cancer research , angiopoietin , vascular endothelial growth factor a , vascular permeability , neovascularization , biology , vegf receptors

There is an unmet need for proangiogenic therapeutic molecules for the treatment of tissue ischemia in cardiovascular diseases. However, major inducers of angiogenesis such as vascular endothelial growth factor (VEGF/VEGF-A) have side effects that limit their therapeutic utility in vivo, especially at high concentrations. Angiopoietin-1 has been considered to be a blood vessel stabilization factor that can inhibit the intrinsic property of VEGF to promote vessel leakiness. In this study, we have designed and tested the angiogenic properties of chimeric molecules consisting of receptor-binding parts of VEGF and angiopoietin-1. We aimed at combining the activities of both factors into 1 molecule for easy delivery and expression in target tissues.

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