Long-Term Heart Transplant Survival by Targeting the Ionotropic Purinergic Receptor P2X7 | Zendy

Andrea Vergani | Zendy; Sara Tezza | Zendy; Francesca D’Addio | Zendy; Carmen Fotino | Zendy; Kaifeng Liu | Zendy; Monika A. Niewczas | Zendy; Roberto Bassi | Zendy; R. Damaris Molano | Zendy; Sonja Kleffel | Zendy; Alessandra Petrelli | Zendy; Antonio Soleti | Zendy; Enrico Ammirati | Zendy; Maria Frigerio | Zendy; Gary Visner | Zendy; Fabio Grassi | Zendy; Maria Elena Ferrero | Zendy; Domenico Corradi | Zendy; Reza Abdi | Zendy; Camillo Ricordi | Zendy; Mohamed H. Sayegh | Zendy; Antonello Pileggi | Zendy; Paolo Fiorina | Zendy

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Long-Term Heart Transplant Survival by Targeting the Ionotropic Purinergic Receptor P2X7

Author(s) -

Andrea Vergani,

Sara Tezza,

Francesca D’Addio,

Carmen Fotino,

Kaifeng Liu,

Monika A. Niewczas,

Roberto Bassi,

R. Damaris Molano,

Sonja Kleffel,

Alessandra Petrelli,

Antonio Soleti,

Enrico Ammirati,

Maria Frigerio,

Gary Visner,

Fabio Grassi,

Maria Elena Ferrero,

Domenico Corradi,

Reza Abdi,

Camillo Ricordi,

Mohamed H. Sayegh,

Antonello Pileggi,

Paolo Fiorina

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.123653

Subject(s) - medicine , purinergic receptor , transplantation , immunology , heart transplantation , downregulation and upregulation , ionotropic effect , t cell , cancer research , immune system , receptor , biology , biochemistry , nmda receptor , gene

Heart transplantation is a lifesaving procedure for patients with end-stage heart failure. Despite much effort and advances in the field, current immunosuppressive regimens are still associated with poor long-term cardiac allograft outcomes, and with the development of complications, including infections and malignancies, as well. The development of a novel, short-term, and effective immunomodulatory protocol will thus be an important achievement. The purine ATP, released during cell damage/activation, is sensed by the ionotropic purinergic receptor P2X7 (P2X7R) on lymphocytes and regulates T-cell activation. Novel clinical-grade P2X7R inhibitors are available, rendering the targeting of P2X7R a potential therapy in cardiac transplantation.

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