A Systems Approach to Designing Effective Clinical Trials Using Simulations | Zendy

Vincent A. Fusaro | Zendy; Prasad Patil | Zendy; Chih-Lin Chi | Zendy; Charles F. Contant | Zendy; Peter J. Tonellato | Zendy

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A Systems Approach to Designing Effective Clinical Trials Using Simulations

Author(s) -

Vincent A. Fusaro,

Prasad Patil,

Chih-Lin Chi,

Charles F. Contant,

Peter J. Tonellato

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.123034

Subject(s) - dosing , medicine , pharmacogenetics , clinical trial , clinical study design , warfarin , protocol (science) , population , pharmacodynamics , intensive care medicine , medical physics , pharmacokinetics , pharmacology , alternative medicine , chemistry , environmental health , genotype , gene , atrial fibrillation , biochemistry , pathology

Pharmacogenetics in warfarin clinical trials have failed to show a significant benefit in comparison with standard clinical therapy. This study demonstrates a computational framework to systematically evaluate preclinical trial design of target population, pharmacogenetic algorithms, and dosing protocols to optimize primary outcomes.

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