Cell Selective Cardiovascular Biology of Microsomal Prostaglandin E Synthase-1 | Zendy

Lihong Chen | Zendy; Guangrui Yang | Zendy; Xiufeng Xu | Zendy; Gregory R. Grant | Zendy; John A. Lawson | Zendy; Mohammad BohloolyY | Zendy; Garret A. FitzGerald | Zendy

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Cell Selective Cardiovascular Biology of Microsomal Prostaglandin E Synthase-1

Author(s) -

Lihong Chen,

Guangrui Yang,

Xiufeng Xu,

Gregory R. Grant,

John A. Lawson,

Mohammad BohloolyY,

Garret A. FitzGerald

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.119479

Subject(s) - medicine , atp synthase , prostaglandin , cell , microbiology and biotechnology , endocrinology , enzyme , biochemistry , biology

Global deletion of microsomal prostaglandin E synthase 1 (mPGES-1) in mice attenuates the response to vascular injury without a predisposition to thrombogenesis or hypertension. However, enzyme deletion results in cell-specific differential use by prostaglandin synthases of the accumulated prostaglandin H(2) substrate. Here, we generated mice deficient in mPGES-1 in vascular smooth muscle cells, endothelial cells, and myeloid cells further to elucidate the cardiovascular function of this enzyme.

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