Uremic Serum and Solutes Increase Post–Vascular Interventional Thrombotic Risk Through Altered Stability of Smooth Muscle Cell Tissue Factor | Zendy

Vipul C. Chitalia | Zendy; Sowmya Shivanna | Zendy; Jordi Martorell | Zendy; Mercedes Balcells | Zendy; Irene Bosch | Zendy; Kumaran Kolandaivelu | Zendy; Elazer R. Edelman | Zendy

Open Access

Uremic Serum and Solutes Increase Post–Vascular Interventional Thrombotic Risk Through Altered Stability of Smooth Muscle Cell Tissue Factor

Author(s) -

Vipul C. Chitalia,

Sowmya Shivanna,

Jordi Martorell,

Mercedes Balcells,

Irene Bosch,

Kumaran Kolandaivelu,

Elazer R. Edelman

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.118174

Subject(s) - medicine , uremia , thrombosis , vascular smooth muscle , endocrinology , hemodialysis , kidney disease , tissue factor , diabetes mellitus , smooth muscle , coagulation

Stent thrombosis (ST), a postinterventional complication with a mortality rate of 50%, has an incidence that rises precipitously in patients at risk. Chronic renal failure and end-stage renal disease have emerged as particularly strong ST risk factors, yet the mechanism remains elusive. Tissue factor (TF) is a crucial mediator of injury-related thrombosis and has been implicated for ST. We posit that uremia modulates TF in the local vessel wall to induce postinterventional thrombosis in patients with end-stage renal disease.

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