Drug Resistance and Pseudoresistance | Zendy

Tilo Großer | Zendy; Susanne Fries | Zendy; John A. Lawson | Zendy; Shiv Kapoor | Zendy; Gregory R. Grant | Zendy; Garret A. FitzGerald | Zendy

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Drug Resistance and Pseudoresistance

Author(s) -

Tilo Großer,

Susanne Fries,

John A. Lawson,

Shiv Kapoor,

Gregory R. Grant,

Garret A. FitzGerald

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.117283

Subject(s) - aspirin , medicine , antiplatelet drug , drug resistance , pharmacology , drug , clopidogrel , biology , microbiology and biotechnology

Low dose aspirin reduces the secondary incidence of myocardial infarction and stroke. Drug resistance to aspirin might result in treatment failure. Despite this concern, no clear definition of aspirin resistance has emerged, and estimates of its incidence have varied remarkably. We aimed to determine the commonality of a mechanistically consistent, stable, and specific phenotype of true pharmacological resistance to aspirin-such as might be explained by genetic causes.

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