Modeling Supravalvular Aortic Stenosis Syndrome With Human Induced Pluripotent Stem Cells | Zendy

Xin Ge | Zendy; Yongming Ren | Zendy; Óscar Bártulos | Zendy; Min Young Lee | Zendy; Zhichao Yue | Zendy; KunYong Kim | Zendy; Wei Li | Zendy; Peter J. Amos | Zendy; Esra Çağavi | Zendy; Amulya Iyer | Zendy; Wei Zheng | Zendy; Hongyu Zhao | Zendy; Kathleen A. Martin | Zendy; Darrell N. Kotton | Zendy; George Tellides | Zendy; InHyun Park | Zendy; Lixia Yue | Zendy; Yibing Qyang | Zendy

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Modeling Supravalvular Aortic Stenosis Syndrome With Human Induced Pluripotent Stem Cells

Author(s) -

Xin Ge,

Yongming Ren,

Óscar Bártulos,

Min Young Lee,

Zhichao Yue,

KunYong Kim,

Wei Li,

Peter J. Amos,

Esra Çağavi,

Amulya Iyer,

Wei Zheng,

Hongyu Zhao,

Kathleen A. Martin,

Darrell N. Kotton,

George Tellides,

InHyun Park,

Lixia Yue,

Yibing Qyang

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.116996

Subject(s) - supravalvular aortic stenosis , medicine , induced pluripotent stem cell , stenosis , cardiology , stem cell , embryonic stem cell , microbiology and biotechnology , genetics , gene , biology

Supravalvular aortic stenosis (SVAS) is caused by mutations in the elastin (ELN) gene and is characterized by abnormal proliferation of vascular smooth muscle cells (SMCs) that can lead to narrowing or blockage of the ascending aorta and other arterial vessels. Having patient-specific SMCs available may facilitate the study of disease mechanisms and development of novel therapeutic interventions.

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