Therapeutic Impact of Follistatin-Like 1 on Myocardial Ischemic Injury in Preclinical Models | Zendy

Yasuhiro Ogura | Zendy; Noriyuki Ouchi | Zendy; Koji Ohashi | Zendy; Rei Shibata | Zendy; Yoshiyuki Kataoka | Zendy; Takahiro Kambara | Zendy; Tetsutaro Kito | Zendy; Sonomi Maruyama | Zendy; Daisuke Yuasa | Zendy; Kazuhiro Matsuo | Zendy; Takashi Enomoto | Zendy; Yusuke Uemura | Zendy; Megumi Miyabe | Zendy; Masakazu Ishii | Zendy; Takashi Yamamoto | Zendy; Yuuki Shimizu | Zendy; Kenneth Walsh | Zendy; Toyoaki Murohara | Zendy

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Therapeutic Impact of Follistatin-Like 1 on Myocardial Ischemic Injury in Preclinical Models

Author(s) -

Yasuhiro Ogura,

Noriyuki Ouchi,

Koji Ohashi,

Rei Shibata,

Yoshiyuki Kataoka,

Takahiro Kambara,

Tetsutaro Kito,

Sonomi Maruyama,

Daisuke Yuasa,

Kazuhiro Matsuo,

Takashi Enomoto,

Yusuke Uemura,

Megumi Miyabe,

Masakazu Ishii,

Takashi Yamamoto,

Yuuki Shimizu,

Kenneth Walsh,

Toyoaki Murohara

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.115089

Subject(s) - proinflammatory cytokine , medicine , cardioprotection , protein kinase a , reperfusion injury , ischemia , myocyte , phosphorylation , endocrinology , inflammation , microbiology and biotechnology , biology

Acute coronary syndrome is a leading cause of death in developed countries. Follistatin-like 1 (FSTL1) is a myocyte-derived secreted protein that is upregulated in the heart in response to ischemic insult. Here, we investigated the therapeutic impact of FSTL1 on acute cardiac injury in small and large preclinical animal models of ischemia/reperfusion and dissected its molecular mechanism.

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