Phosphoinositide 3-Kinase γ Protects Against Catecholamine-Induced Ventricular Arrhythmia Through Protein Kinase A–Mediated Regulation of Distinct Phosphodiesterases | Zendy

Alessandra Ghigo | Zendy; Alessia Perino | Zendy; Hind Mehel | Zendy; Alexandra Zahradníková | Zendy; Fulvio Morello | Zendy; Jérôme Leroy | Zendy; Viacheslav O. Nikolaev | Zendy; Federico Damilano | Zendy; James J. Cimino | Zendy; Elisa De Luca | Zendy; Wito Richter | Zendy; Ruth E. Westenbroek | Zendy; William A. Catterall | Zendy; Jin Zhang | Zendy; Chen Yan | Zendy; Marco Conti | Zendy; Ana M. Gómez | Zendy; Grégoire Vandecasteele | Zendy; Emilio Hirsch | Zendy; Rodolphe Fischmeister | Zendy

Open Access

Phosphoinositide 3-Kinase γ Protects Against Catecholamine-Induced Ventricular Arrhythmia Through Protein Kinase A–Mediated Regulation of Distinct Phosphodiesterases

Author(s) -

Alessandra Ghigo,

Alessia Perino,

Hind Mehel,

Alexandra Zahradníková,

Fulvio Morello,

Jérôme Leroy,

Viacheslav O. Nikolaev,

Federico Damilano,

James J. Cimino,

Elisa De Luca,

Wito Richter,

Ruth E. Westenbroek,

William A. Catterall,

Jin Zhang,

Chen Yan,

Marco Conti,

Ana M. Gómez,

Grégoire Vandecasteele,

Emilio Hirsch,

Rodolphe Fischmeister

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.114074

Subject(s) - medicine , phosphoinositide 3 kinase , protein kinase a , phosphodiesterase , catecholamine , kinase , microbiology and biotechnology , pharmacology , endocrinology , signal transduction , enzyme , pi3k/akt/mtor pathway , biology , biochemistry

Phosphoinositide 3-kinase γ (PI3Kγ) signaling engaged by β-adrenergic receptors is pivotal in the regulation of myocardial contractility and remodeling. However, the role of PI3Kγ in catecholamine-induced arrhythmia is currently unknown.

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