Dietary Nitrate Supplementation Improves Revascularization in Chronic Ischemia | Zendy

Ulrike B. HendgenCotta | Zendy; Peter Luedike | Zendy; Matthias Totzeck | Zendy; Martina Kropp | Zendy; Andreas Schicho | Zendy; Pia Stock | Zendy; Christos Rammos | Zendy; Michael Nießen | Zendy; Christian Heiß | Zendy; Jon O. Lundberg | Zendy; Eddie Weitzberg | Zendy; Malte Kelm | Zendy; Tienush Rassaf | Zendy

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Dietary Nitrate Supplementation Improves Revascularization in Chronic Ischemia

Author(s) -

Ulrike B. HendgenCotta,

Peter Luedike,

Matthias Totzeck,

Martina Kropp,

Andreas Schicho,

Pia Stock,

Christos Rammos,

Michael Nießen,

Christian Heiß,

Jon O. Lundberg,

Eddie Weitzberg,

Malte Kelm,

Tienush Rassaf

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.112912

Subject(s) - medicine , nitric oxide , ischemia , cd31 , revascularization , nitrate , pharmacology , surgery , angiogenesis , endocrinology , chemistry , myocardial infarction , organic chemistry

Revascularization is an adaptive repair mechanism that restores blood flow to undersupplied ischemic tissue. Nitric oxide plays an important role in this process. Whether dietary nitrate, serially reduced to nitrite by commensal bacteria in the oral cavity and subsequently to nitric oxide and other nitrogen oxides, enhances ischemia-induced remodeling of the vascular network is not known.

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