Altered Activation of Endothelial Anti- and Proapoptotic Pathways by High-Density Lipoprotein from Patients with Coronary Artery Disease | Zendy

Meliana Riwanto | Zendy; Lucia Rohrer | Zendy; Bernd Roschitzki | Zendy; Christian Besler | Zendy; Pavani Mocharla | Zendy; Maja Mueller | Zendy; Damir Perisa | Zendy; Kathrin Heinrich | Zendy; Lukas Altwegg | Zendy; Arnold von Eckardstein | Zendy; Thomas F. Lüscher | Zendy; Ulf Landmesser | Zendy

Open Access

Altered Activation of Endothelial Anti- and Proapoptotic Pathways by High-Density Lipoprotein from Patients with Coronary Artery Disease

Author(s) -

Meliana Riwanto,

Lucia Rohrer,

Bernd Roschitzki,

Christian Besler,

Pavani Mocharla,

Maja Mueller,

Damir Perisa,

Kathrin Heinrich,

Lukas Altwegg,

Arnold von Eckardstein,

Thomas F. Lüscher,

Ulf Landmesser

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.108753

Subject(s) - medicine , endothelial dysfunction , apolipoprotein b , lipoprotein , high density lipoprotein , endothelium , endocrinology , clusterin , apoptosis , coronary artery disease , cholesterol , biology , biochemistry

Endothelial dysfunction and injury are thought to play an important role in the progression of coronary artery disease (CAD). High-density lipoprotein from healthy subjects (HDL(Healthy)) has been proposed to exert endothelial antiapoptotic effects that may represent an important antiatherogenic property of the lipoprotein. The present study therefore aimed to compare effects of HDL(CAD) and HDL(Healthy) on the activation of endothelial anti- and proapoptotic pathways and to determine which changes of the lipoprotein are relevant for these processes.

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