Nucleotide Excision DNA Repair Is Associated With Age-Related Vascular Dysfunction | Zendy

Matej Durik | Zendy; Maryam Kavousi | Zendy; Ingrid van der Pluijm | Zendy; Aaron Isaacs | Zendy; Caroline Cheng | Zendy; Koen Verdonk | Zendy; Annemarieke E. Loot | Zendy; Hisko Oeseburg | Zendy; Usha M. Bhaggoe | Zendy; Frank Leijten | Zendy; Richard van Veghel | Zendy; René de Vries | Zendy; Goran Rudež | Zendy; Renata M. C. Brandt | Zendy; Yanto Ridwan | Zendy; Elza D. van Deel | Zendy; Martine de Boer | Zendy; Dennie Tempel | Zendy; Ingrid Fleming | Zendy; Gary F. Mitchell | Zendy; Germaine C. Verwoert | Zendy; Kirill V. Tarasov | Zendy; André G. Uitterlinden | Zendy; Albert Hofman | Zendy; Henricus J. Duckers | Zendy; Cornelia M. van Duijn | Zendy; Ben A. Oostra | Zendy; Jacqueline C.M. Witteman | Zendy; Dirk J. Duncker | Zendy; A.H. Jan Danser | Zendy; Jan H.J. Hoeijmakers | Zendy; Anton J.M. Roks | Zendy

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Nucleotide Excision DNA Repair Is Associated With Age-Related Vascular Dysfunction

Author(s) -

Matej Durik,

Maryam Kavousi,

Ingrid van der Pluijm,

Aaron Isaacs,

Caroline Cheng,

Koen Verdonk,

Annemarieke E. Loot,

Hisko Oeseburg,

Usha M. Bhaggoe,

Frank Leijten,

Richard van Veghel,

René de Vries,

Goran Rudež,

Renata M. C. Brandt,

Yanto Ridwan,

Elza D. van Deel,

Martine de Boer,

Dennie Tempel,

Ingrid Fleming,

Gary F. Mitchell,

Germaine C. Verwoert,

Kirill V. Tarasov,

André G. Uitterlinden,

Albert Hofman,

Henricus J. Duckers,

Cornelia M. van Duijn,

Ben A. Oostra,

Jacqueline C.M. Witteman,

Dirk J. Duncker,

A.H. Jan Danser,

Jan H.J. Hoeijmakers,

Anton J.M. Roks

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.104380

Subject(s) - ercc1 , endothelial dysfunction , nucleotide excision repair , genome instability , dna repair , medicine , senescence , dna damage , vasodilation , oxidative stress , endocrinology , biology , genetics , gene , dna

Vascular dysfunction in atherosclerosis and diabetes mellitus, as observed in the aging population of developed societies, is associated with vascular DNA damage and cell senescence. We hypothesized that cumulative DNA damage during aging contributes to vascular dysfunction.

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