Myocardial Notch Signaling Reprograms Cardiomyocytes to a Conduction-Like Phenotype | Zendy

Stacey Rentschler | Zendy; Alberta Yen | Zendy; Jia Lu | Zendy; Nataliya Petrenko | Zendy; Min Lü | Zendy; Lauren J. Manderfield | Zendy; Vickas V. Patel | Zendy; Glenn I. Fishman | Zendy; Jonathan A. Epstein | Zendy

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Myocardial Notch Signaling Reprograms Cardiomyocytes to a Conduction-Like Phenotype

Author(s) -

Stacey Rentschler,

Alberta Yen,

Jia Lu,

Nataliya Petrenko,

Min Lü,

Lauren J. Manderfield,

Vickas V. Patel,

Glenn I. Fishman,

Jonathan A. Epstein

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.103390

Subject(s) - notch signaling pathway , reprogramming , microbiology and biotechnology , phenotype , cell fate determination , electrical conduction system of the heart , transcriptome , biology , cellular differentiation , hes3 signaling axis , ectopic expression , stem cell , signal transduction , neuroscience , medicine , cell , transcription factor , genetics , gene , gene expression , electrocardiography

Notch signaling has previously been shown to play an essential role in regulating cell fate decisions and differentiation during cardiogenesis in many systems including Drosophila, Xenopus, and mammals. We hypothesized that Notch may also be involved in directing the progressive lineage restriction of cardiomyocytes into specialized conduction cells.

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