Open AccessGap Junctions and Connexin Hemichannels Underpin Hemostasis and Thrombosis
Author(s) -
Sakthivel Vaiyapuri,
Chris I. Jones,
Parvathy Sasikumar,
Leonardo A. Moraes,
Stephanie J. Munger,
Joy R. Wright,
Marfoua S. Ali,
Tanya Sage,
William J. Kaiser,
Katherine L. Tucker,
Christopher J. Stain,
Alexander P. Bye,
Sarah Jones,
Ernesto OviedoOrta,
Alexander M. Simon,
Martyn P. MahautSmith,
Jonathan M. Gibbins
Publication year - 2012
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.112.101246
Subject(s) - gap junction , connexon , connexin , platelet , hemostasis , microbiology and biotechnology , thrombus , medicine , thrombosis , platelet activation , clot retraction , immunology , intracellular , biology , thrombin
Connexins are a widespread family of membrane proteins that assemble into hexameric hemichannels, also known as connexons. Connexons regulate membrane permeability in individual cells or couple between adjacent cells to form gap junctions and thereby provide a pathway for regulated intercellular communication. We have examined the role of connexins in platelets, blood cells that circulate in isolation but on tissue injury adhere to each other and the vessel wall to prevent blood loss and to facilitate wound repair.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom