Open AccessDietary Nitrate Ameliorates Pulmonary Hypertension
Author(s) -
Reshma S. Baliga,
Alexandra Milsom,
Suborno M. Ghosh,
Sarah L. Trinder,
Raymond J. MacAllister,
Amrita Ahluwalia,
Adrian J. Hobbs
Publication year - 2012
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.112.100586
Subject(s) - nitrite , pulmonary hypertension , medicine , nitrate , nitric oxide , right ventricular hypertrophy , hypoxia (environmental) , allopurinol , vascular resistance , blood pressure , pharmacology , cardiology , endocrinology , chemistry , oxygen , organic chemistry
Pulmonary hypertension (PH) is a multifactorial disease characterized by increased pulmonary vascular resistance and right ventricular failure; morbidity and mortality remain unacceptably high. Loss of nitric oxide (NO) bioactivity is thought to contribute to the pathogenesis of PH, and agents that augment pulmonary NO signaling are clinically effective in the disease. Inorganic nitrate (NO(3)(-)) and nitrite (NO(2)(-)) elicit a reduction in systemic blood pressure in healthy individuals; this effect is underpinned by endogenous and sequential reduction to NO. Herein, we determined whether dietary nitrate and nitrite might be preferentially reduced to NO by the hypoxia associated with PH, and thereby offer a convenient, inexpensive method of supplementing NO functionality to reduce disease severity.
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