Neutrophil-Derived Matrix Metalloproteinase 9 Triggers Acute Aortic Dissection | Zendy

Tomohiro Kurihara | Zendy; Ryoko ShimizuHirota | Zendy; Masayuki Shimoda | Zendy; Takeshi Adachi | Zendy; Hideyuki Shimizu | Zendy; Stephen J. Weiss | Zendy; Hiroshi Itoh | Zendy; Shingo Hori | Zendy; Naoki Aikawa | Zendy; Yasunori Okada | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Neutrophil-Derived Matrix Metalloproteinase 9 Triggers Acute Aortic Dissection

Author(s) -

Tomohiro Kurihara,

Ryoko ShimizuHirota,

Masayuki Shimoda,

Takeshi Adachi,

Hideyuki Shimizu,

Stephen J. Weiss,

Hiroshi Itoh,

Shingo Hori,

Naoki Aikawa,

Yasunori Okada

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.097097

Subject(s) - medicine , angiotensin ii , matrix metalloproteinase , aortic dissection , aorta , aortic aneurysm , thoracic aorta , gelatinase , timp1 , mmp9 , immunology , pathology , receptor , gene expression , downregulation and upregulation , biochemistry , chemistry , gene

Acute aortic dissection (AAD) is a life-threatening vascular disease without effective pharmaceutical therapy. Matrix metalloproteinases (MMPs) are implicated in the development of chronic vascular diseases including aneurysm, but the key effectors and mechanism of action remain unknown. To define further the role of MMPs in AAD, we screened circulating MMPs in AAD patients, and then generated a novel mouse model for AAD to characterize the mechanism of action.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research