Open AccessDipeptidyl Peptidase-4 Modulates Left Ventricular Dysfunction in Chronic Heart Failure via Angiogenesis-Dependent and -Independent Actions
Author(s) -
Toshimasa Shigeta,
Morihiko Aoyama,
Yoshiyuki Bando,
Akio Monji,
Toko Mitsui,
Miwa Takatsu,
Xiang-Wu Cheng,
Takahiro Okumura,
Akihiro Hirashiki,
Kohzo Nagata,
Toyoaki Murohara
Publication year - 2012
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.112.096479
Subject(s) - medicine , dipeptidyl peptidase 4 , heart failure , cardiology , endocrinology , diabetes mellitus , angiogenesis , type 2 diabetes
The inhibition of dipeptidyl peptidase-4 (DPP4) protects the heart from acute myocardial ischemia. However, the role of DPP4 in chronic heart failure independent of coronary artery disease remains unclear.
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