Multiple Reaction Monitoring to Identify Site-Specific Troponin I Phosphorylated Residues in the Failing Human Heart | Zendy

Pingbo Zhang | Zendy; Jonathan A. Kirk | Zendy; Weihua Ji | Zendy; Cristobal G. dos Remedios | Zendy; David A. Kass | Zendy; Jennifer E. Van Eyk | Zendy; Anne M. Murphy | Zendy

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Multiple Reaction Monitoring to Identify Site-Specific Troponin I Phosphorylated Residues in the Failing Human Heart

Author(s) -

Pingbo Zhang,

Jonathan A. Kirk,

Weihua Ji,

Cristobal G. dos Remedios,

David A. Kass,

Jennifer E. Van Eyk,

Anne M. Murphy

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.096388

Subject(s) - phosphorylation , heart failure , troponin i , troponin , medicine , kinase , cardiology , protein phosphorylation , heart transplantation , protein kinase a , biochemistry , chemistry , myocardial infarction

Human cardiac troponin I is known to be phosphorylated at multiple amino acid residues by several kinases. Advances in mass spectrometry allow sensitive detection of known and novel phosphorylation sites and measurement of the level of phosphorylation simultaneously at each site in myocardial samples.

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