Loss of AngiomiR-126 and 130a in Angiogenic Early Outgrowth Cells From Patients With Chronic Heart Failure | Zendy

Philipp Jakob | Zendy; Carola Doerries | Zendy; Sylvie Briand | Zendy; Pavani Mocharla | Zendy; Nicolle Kränkel | Zendy; Christian Besler | Zendy; Maja Mueller | Zendy; Costantina Manes | Zendy; Christian Templin | Zendy; Christof Baltes | Zendy; Markus Rudin | Zendy; Heiner Adams | Zendy; Mathias Wolfrum | Zendy; Georg Noll | Zendy; Frank Ruschitzka | Zendy; Thomas F. Lüscher | Zendy; Ulf Landmesser | Zendy

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Loss of AngiomiR-126 and 130a in Angiogenic Early Outgrowth Cells From Patients With Chronic Heart Failure

Author(s) -

Philipp Jakob,

Carola Doerries,

Sylvie Briand,

Pavani Mocharla,

Nicolle Kränkel,

Christian Besler,

Maja Mueller,

Costantina Manes,

Christian Templin,

Christof Baltes,

Markus Rudin,

Heiner Adams,

Mathias Wolfrum,

Georg Noll,

Frank Ruschitzka,

Thomas F. Lüscher,

Ulf Landmesser

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.093906

Subject(s) - medicine , angiogenesis , neovascularization , cd34 , transplantation , cardiac function curve , heart failure , cancer research , stem cell , immunology , biology , microbiology and biotechnology

MicroRNAs are key regulators of angiogenic processes. Administration of angiogenic early outgrowth cells (EOCs) or CD34(+) cells has been suggested to improve cardiac function after ischemic injury, in particular by promoting neovascularization. The present study therefore examines regulation of angiomiRs, microRNAs involved in angiogenesis, in angiogenic EOCs and circulating CD34(+) cells from patients with chronic heart failure (CHF) and the role for their cardiac repair capacity.

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