Noninvasive Magnetic Resonance Imaging Evaluation of Endothelial Permeability in Murine Atherosclerosis Using an Albumin-Binding Contrast Agent | Zendy

Alkystis Phinikaridou | Zendy; Marcelo E. Andía | Zendy; Andrea Protti | Zendy; Andreas Indermuehle | Zendy; Ajay M. Shah | Zendy; Alberto Smith | Zendy; Alice Warley | Zendy; René M. Botnar | Zendy

Open Access

Noninvasive Magnetic Resonance Imaging Evaluation of Endothelial Permeability in Murine Atherosclerosis Using an Albumin-Binding Contrast Agent

Author(s) -

Alkystis Phinikaridou,

Marcelo E. Andía,

Andrea Protti,

Andreas Indermuehle,

Ajay M. Shah,

Alberto Smith,

Alice Warley,

René M. Botnar

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.092098

Subject(s) - medicine , apolipoprotein e , endothelial dysfunction , endothelial stem cell , magnetic resonance imaging , endothelium , evans blue , vascular permeability , vasodilation , endocrinology , pathology , chemistry , radiology , in vitro , biochemistry , disease

Endothelial dysfunction promotes atherosclerosis and precedes acute cardiovascular events. We investigated whether in vivo magnetic resonance imaging with the use of an albumin-binding contrast agent, gadofosveset, could detect endothelial damage associated with atherosclerosis in apolipoprotein E-deficient (ApoE(-/-)) mice. Furthermore, we tested whether magnetic resonance imaging could noninvasively assess endothelial function by measuring the endothelial-dependent vasodilation in response to acetylcholine.

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