Human Genome-Wide Association and Mouse Knockout Approaches Identify Platelet Supervillin as an Inhibitor of Thrombus Formation Under Shear Stress | Zendy

Leonard C. Edelstein | Zendy; Elizabeth J. Luna | Zendy; Ian B. Gibson | Zendy; Molly S. Bray | Zendy; Ying Jin | Zendy; Altaf A. Kondkar | Zendy; Srikanth Nagalla | Zendy; Nacima Hadjout-Rabi | Zendy; Tara C. Smith | Zendy; Daniel Covarrubias | Zendy; Stephen N. Jones | Zendy; Firdos Ahmad | Zendy; Moritz Stolla | Zendy; Xianguo Kong | Zendy; Zhiyou Fang | Zendy; Wolfgang Bergmeier | Zendy; Chad A. Shaw | Zendy; Suzanne M. Leal | Zendy; Paul F. Bray | Zendy

Open Access

Human Genome-Wide Association and Mouse Knockout Approaches Identify Platelet Supervillin as an Inhibitor of Thrombus Formation Under Shear Stress

Author(s) -

Leonard C. Edelstein,

Elizabeth J. Luna,

Ian B. Gibson,

Molly S. Bray,

Ying Jin,

Altaf A. Kondkar,

Srikanth Nagalla,

Nacima Hadjout-Rabi,

Tara C. Smith,

Daniel Covarrubias,

Stephen N. Jones,

Firdos Ahmad,

Moritz Stolla,

Xianguo Kong,

Zhiyou Fang,

Wolfgang Bergmeier,

Chad A. Shaw,

Suzanne M. Leal,

Paul F. Bray

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.091462

Subject(s) - platelet , thrombus , platelet activation , medicine , shear stress , microbiology and biotechnology , pathology , immunology , biology , materials science , composite material

High shear force critically regulates platelet adhesion and thrombus formation during ischemic vascular events. To identify genetic factors that influence platelet thrombus formation under high shear stress, we performed a genome-wide association study and confirmatory experiments in human and animal platelets.

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