Macrophage MicroRNA-155 Promotes Cardiac Hypertrophy and Failure | Zendy

Stéphane Heymans | Zendy; Maarten F. Corsten | Zendy; Wouter Verhesen | Zendy; Paolo Carai | Zendy; Rick E.W. van Leeuwen | Zendy; Kevin Custers | Zendy; T. J. Peters | Zendy; Mark R. Hazebroek | Zendy; J. Lauran Stöger | Zendy; Erwin Wijnands | Zendy; Ben Janssen | Zendy; Esther E. Creemers | Zendy; Yigal M. Pinto | Zendy; Dirk Grimm | Zendy; Nina Schürmann | Zendy; Elena Vigorito | Zendy; Thomas Thum | Zendy; Frank Stassen | Zendy; Xiaoke Yin | Zendy; Manuel Mayr | Zendy; León J. De Windt | Zendy; Esther Lutgens | Zendy; Kristiaan Wouters | Zendy; Menno P.J. de Winther | Zendy; Serena Zacchigna | Zendy; Mauro Giacca | Zendy; Marc van Bilsen | Zendy; AnnaPia Papageorgiou | Zendy; Blanche Schroen | Zendy

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Macrophage MicroRNA-155 Promotes Cardiac Hypertrophy and Failure

Author(s) -

Stéphane Heymans,

Maarten F. Corsten,

Wouter Verhesen,

Paolo Carai,

Rick E.W. van Leeuwen,

Kevin Custers,

T. J. Peters,

Mark R. Hazebroek,

J. Lauran Stöger,

Erwin Wijnands,

Ben Janssen,

Esther E. Creemers,

Yigal M. Pinto,

Dirk Grimm,

Nina Schürmann,

Elena Vigorito,

Thomas Thum,

Frank Stassen,

Xiaoke Yin,

Manuel Mayr,

León J. De Windt,

Esther Lutgens,

Kristiaan Wouters,

Menno P.J. de Winther,

Serena Zacchigna,

Mauro Giacca,

Marc van Bilsen,

AnnaPia Papageorgiou,

Blanche Schroen

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.001357

Subject(s) - medicine , inflammation , pressure overload , microrna , heart failure , muscle hypertrophy , mir 155 , knockout mouse , paracrine signalling , cardiac myocyte , myocarditis , myocyte , cancer research , immunology , biology , receptor , cardiac hypertrophy , biochemistry , gene

Cardiac hypertrophy and subsequent heart failure triggered by chronic hypertension represent major challenges for cardiovascular research. Beyond neurohormonal and myocyte signaling pathways, growing evidence suggests inflammatory signaling pathways as therapeutically targetable contributors to this process. We recently reported that microRNA-155 is a key mediator of cardiac inflammation and injury in infectious myocarditis. Here, we investigated the impact of microRNA-155 manipulation in hypertensive heart disease.

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