Cytotoxic and Proinflammatory CD8 + T Lymphocytes Promote Development of Vulnerable Atherosclerotic Plaques in ApoE-Deficient Mice | Zendy

Tin Kyaw | Zendy; Amy Winship | Zendy; Christopher Tay | Zendy; Peter Kanellakis | Zendy; Hamid Hosseini | Zendy; Anh Cao | Zendy; Priscilla Li | Zendy; Peter G. Tipping | Zendy; Alex Bobik | Zendy; BanHock Toh | Zendy

Open Access

Cytotoxic and Proinflammatory CD8 ⁺ T Lymphocytes Promote Development of Vulnerable Atherosclerotic Plaques in ApoE-Deficient Mice

Author(s) -

Tin Kyaw,

Amy Winship,

Christopher Tay,

Peter Kanellakis,

Hamid Hosseini,

Anh Cao,

Priscilla Li,

Peter G. Tipping,

Alex Bobik,

BanHock Toh

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.001347

Subject(s) - cytotoxic t cell , granzyme b , cd8 , medicine , perforin , inflammation , immunology , biology , pathology , immune system , biochemistry , in vitro

Heart attacks and strokes, leading causes of deaths globally, arise from thrombotic occlusion of ruptured vulnerable atherosclerotic plaques characterized by abundant apoptosis, large necrotic cores derived from inefficient apoptotic cell clearance, thin fibrous caps, and focal inflammation. The genesis of apoptosis and necrotic cores in these vulnerable atherosclerotic plaques remains unknown. Cytotoxic CD8(+) T lymphocytes represent up to 50% of leukocytes in advanced human plaques and dominate early immune responses in mouse lesions, yet their role in atherosclerosis also remains unresolved.

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