Divergent Mitochondrial Biogenesis Responses in Human Cardiomyopathy
Author(s) -
Preeti Ahuja,
Jonathan Wanagat,
Wang Zh,
Yibin Wang,
David A. Liem,
Peipei Ping,
Igor Antoshechkin,
Kenneth B. Margulies,
W. Robb MacLellan
Publication year - 2013
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.112.001219
Subject(s) - mitochondrial biogenesis , dilated cardiomyopathy , heart failure , medicine , mitochondrial dna , cardiomyopathy , cardiology , mitochondrion , endocrinology , gene , biology , microbiology and biotechnology , genetics
Mitochondria are key players in the development and progression of heart failure (HF). Mitochondrial (mt) dysfunction leads to diminished energy production and increased cell death contributing to the progression of left ventricular failure. The fundamental mechanisms that underlie mt dysfunction in HF have not been fully elucidated.
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