Integrin α 6 β 1 Is the Main Receptor for Vascular Laminins and Plays a Role in Platelet Adhesion, Activation, and Arterial Thrombosis | Zendy

Mathieu Schaff | Zendy; Chaojun Tang | Zendy; Éric Maurer | Zendy; Catherine Bourdon | Zendy; Nicolas Receveur | Zendy; Anita Eckly | Zendy; Béatrice Hechler | Zendy; Christiane Arnold | Zendy; Adèle De Arcangelis | Zendy; Bernhard Nieswandt | Zendy; Cécile V. Denis | Zendy; Olivier Lefèbvre | Zendy; Elisabeth GeorgesLabouesse | Zendy; Christian Gachet | Zendy; François Lanza | Zendy; P Mangin | Zendy

Open Access

Integrin α ₆ β ₁ Is the Main Receptor for Vascular Laminins and Plays a Role in Platelet Adhesion, Activation, and Arterial Thrombosis

Author(s) -

Mathieu Schaff,

Chaojun Tang,

Éric Maurer,

Catherine Bourdon,

Nicolas Receveur,

Anita Eckly,

Béatrice Hechler,

Christiane Arnold,

Adèle De Arcangelis,

Bernhard Nieswandt,

Cécile V. Denis,

Olivier Lefèbvre,

Elisabeth GeorgesLabouesse,

Christian Gachet,

François Lanza,

P Mangin

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.000799

Subject(s) - medicine , integrin , thrombosis , platelet activation , platelet , platelet adhesion , receptor , vascular disease , cardiology

Laminins are major components of basement membranes, well located to interact with platelets upon vascular injury. Laminin-111 (α1β1γ1) is known to support platelet adhesion but is absent from most blood vessels, which contain isoforms with the α2, α4, or α5 chain. Whether vascular laminins support platelet adhesion and activation and the significance of these interactions in hemostasis and thrombosis remain unknown.

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