Donor Brain Death Exacerbates Complement-Dependent Ischemia/Reperfusion Injury in Transplanted Hearts | Zendy

Carl Atkinson | Zendy; Bernhard Floerchinger | Zendy; Fei Qiao | Zendy; Sarah Casey | Zendy; Tucker Williamson | Zendy; E. Moseley | Zendy; Șerban Stoica | Zendy; Martin Goddard | Zendy; Xupeng Ge | Zendy; Stefan G. Tullius | Zendy; Stephen Tomlinson | Zendy

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Donor Brain Death Exacerbates Complement-Dependent Ischemia/Reperfusion Injury in Transplanted Hearts

Author(s) -

Carl Atkinson,

Bernhard Floerchinger,

Fei Qiao,

Sarah Casey,

Tucker Williamson,

E. Moseley,

Șerban Stoica,

Martin Goddard,

Xupeng Ge,

Stefan G. Tullius,

Stephen Tomlinson

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.000784

Subject(s) - medicine , ischemia , reperfusion injury , cardiology , complement (music) , complement system , immunology , antibody , biochemistry , chemistry , complementation , gene , phenotype

Brain death (BD) can immunologically prime the donor organ and is thought to lead to exacerbated ischemia/reperfusion injury after transplantation. Using a newly developed mouse model of BD, we investigated the effect of donor BD on posttransplantation cardiac ischemia/reperfusion injury. We further investigated the therapeutic effect of a targeted complement inhibitor in recipients of BD donor hearts and addressed the clinical relevance of these studies by analyzing human heart biopsies from BD and domino (living) donors.

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