Vascular Endothelial Adrenomedullin-RAMP2 System Is Essential for Vascular Integrity and Organ Homeostasis | Zendy

Teruhide Koyama | Zendy; Laura OchoaCallejero | Zendy; Takayuki Sakurai | Zendy; Akiko Kamiyoshi | Zendy; Yuka IchikawaShindo | Zendy; Nobuyoshi Iinuma | Zendy; T. Arai | Zendy; Takahiro Yoshizawa | Zendy; Yasuhiro Iesato | Zendy; Lei Yang | Zendy; Ryuichi Uetake | Zendy; Ayano Okimura | Zendy; Akihiro Yamauchi | Zendy; Megumu Tanaka | Zendy; Kyoko Igarashi | Zendy; Yuichi Toriyama | Zendy; Hisaka Kawate | Zendy; Ralf H. Adams | Zendy; Hayato Kawakami | Zendy; Naoki Mochizuki | Zendy; Alfredo Martı́nez | Zendy; Takayuki Shindo | Zendy

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Vascular Endothelial Adrenomedullin-RAMP2 System Is Essential for Vascular Integrity and Organ Homeostasis

Author(s) -

Teruhide Koyama,

Laura OchoaCallejero,

Takayuki Sakurai,

Akiko Kamiyoshi,

Yuka IchikawaShindo,

Nobuyoshi Iinuma,

T. Arai,

Takahiro Yoshizawa,

Yasuhiro Iesato,

Lei Yang,

Ryuichi Uetake,

Ayano Okimura,

Akihiro Yamauchi,

Megumu Tanaka,

Kyoko Igarashi,

Yuichi Toriyama,

Hisaka Kawate,

Ralf H. Adams,

Hayato Kawakami,

Naoki Mochizuki,

Alfredo Martı́nez,

Takayuki Shindo

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.000756

Subject(s) - adrenomedullin , medicine , cardiac fibrosis , microbiology and biotechnology , cancer research , biology , endocrinology , fibrosis , receptor

Revealing the mechanisms underlying the functional integrity of the vascular system could make available novel therapeutic approaches. We previously showed that knocking out the widely expressed peptide adrenomedullin (AM) or receptor activity-modifying protein 2 (RAMP2), an AM-receptor accessory protein, causes vascular abnormalities and is embryonically lethal. Our aim was to investigate the function of the vascular AM-RAMP2 system directly.

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