Mild Renal Dysfunction and Metabolites Tied to Low HDL Cholesterol Are Associated With Monocytosis and Atherosclerosis | Zendy

Anjali Ganda | Zendy; Martin Magnusson | Zendy; Laurent YvanCharvet | Zendy; Bo Hedblad | Zendy; Gunnar Engström | Zendy; Ding Ai | Zendy; Thomas J. Wang | Zendy; Robert E. Gerszten | Zendy; Olle Melander | Zendy; Alan R. Tall | Zendy

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Mild Renal Dysfunction and Metabolites Tied to Low HDL Cholesterol Are Associated With Monocytosis and Atherosclerosis

Author(s) -

Anjali Ganda,

Martin Magnusson,

Laurent YvanCharvet,

Bo Hedblad,

Gunnar Engström,

Ding Ai,

Thomas J. Wang,

Robert E. Gerszten,

Olle Melander,

Alan R. Tall

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.000682

Subject(s) - medicine , cystatin c , endocrinology , monocyte , cholesterol , monocytosis , lipoprotein , high density lipoprotein , cystatin , insulin resistance , renal function , insulin , bone marrow

The number of circulating blood monocytes impacts atherosclerotic lesion size, and in mouse models, elevated levels of high-density lipoprotein cholesterol suppress blood monocyte counts and atherosclerosis. We hypothesized that individuals with mild renal dysfunction at increased cardiovascular risk would have reduced high-density lipoprotein levels, high blood monocyte counts, and accelerated atherosclerosis.

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