Screening Drug-Induced Arrhythmia Using Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes and Low-Impedance Microelectrode Arrays | Zendy

Enrique G. Navarrete | Zendy; Ping Liang | Zendy; Feng Lan | Zendy; Verónica Sánchez-Freire | Zendy; Chelsey S. Simmons | Zendy; Tingyu Gong | Zendy; Arun Sharma | Zendy; Paul W. Burridge | Zendy; Bhagat Patlolla | Zendy; Andrew S. Lee | Zendy; Haodi Wu | Zendy; Ramin E. Beygui | Zendy; Sean M. Wu | Zendy; Robert C. Robbins | Zendy; Donald M. Bers | Zendy; Joseph C. Wu | Zendy

Open Access

Screening Drug-Induced Arrhythmia Using Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes and Low-Impedance Microelectrode Arrays

Author(s) -

Enrique G. Navarrete,

Ping Liang,

Feng Lan,

Verónica Sánchez-Freire,

Chelsey S. Simmons,

Tingyu Gong,

Arun Sharma,

Paul W. Burridge,

Bhagat Patlolla,

Andrew S. Lee,

Haodi Wu,

Ramin E. Beygui,

Sean M. Wu,

Robert C. Robbins,

Donald M. Bers,

Joseph C. Wu

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.000570

Subject(s) - induced pluripotent stem cell , quinidine , medicine , herg , afterdepolarization , multielectrode array , pharmacology , embryoid body , sotalol , cardiotoxicity , drug , embryonic stem cell , electrophysiology , potassium channel , microelectrode , repolarization , atrial fibrillation , toxicity , biology , chemistry , biochemistry , electrode , gene

Drug-induced arrhythmia is one of the most common causes of drug development failure and withdrawal from market. This study tested whether human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) combined with a low-impedance microelectrode array (MEA) system could improve on industry-standard preclinical cardiotoxicity screening methods, identify the effects of well-characterized drugs, and elucidate underlying risk factors for drug-induced arrhythmia. hiPSC-CMs may be advantageous over immortalized cell lines because they possess similar functional characteristics as primary human cardiomyocytes and can be generated in unlimited quantities.

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