Creation of Nonischemic Functional Mitral Regurgitation by Annular Dilatation and Nonplanar Modification in a Chronic In Vivo Swine Model | Zendy

Haruo Yamauchi | Zendy; Eric N. Feins | Zendy; Nikolay V. Vasilyev | Zendy; Shogo Shimada | Zendy; David Zurakowski | Zendy; Pedro J. del Nido | Zendy

Open Access

Creation of Nonischemic Functional Mitral Regurgitation by Annular Dilatation and Nonplanar Modification in a Chronic In Vivo Swine Model

Author(s) -

Haruo Yamauchi,

Eric N. Feins,

Nikolay V. Vasilyev,

Shogo Shimada,

David Zurakowski,

Pedro J. del Nido

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.000396

Subject(s) - vena contracta , medicine , mitral regurgitation , annulus (botany) , ventricle , mitral valve , cardiology , papillary muscle , mitral annulus , diastole , blood pressure , botany , biology

Mechanisms and treatments of nonischemic functional mitral regurgitation (NIMR) are not fully established, in part, because of a lack of proper large animal models. We developed a novel technique of NIMR creation in a swine model by making multiple small incisions in the mitral annulus.

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