Reproducible Porcine Model of Thoracic Aortic Aneurysm | Zendy

Shaina R. Eckhouse | Zendy; Christina B. Logdon | Zendy; J. Marshall Oelsen | Zendy; Risha K. Patel | Zendy; Allison Rice | Zendy; Robert E. Stroud | Zendy; W. Benjamin Wince | Zendy; Rupak Mukherjee | Zendy; Francis G. Spinale | Zendy; John S. Ikonomidis | Zendy; Jeffrey A. Jones | Zendy

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Reproducible Porcine Model of Thoracic Aortic Aneurysm

Author(s) -

Shaina R. Eckhouse,

Christina B. Logdon,

J. Marshall Oelsen,

Risha K. Patel,

Allison Rice,

Robert E. Stroud,

W. Benjamin Wince,

Rupak Mukherjee,

Francis G. Spinale,

John S. Ikonomidis,

Jeffrey A. Jones

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.000363

Subject(s) - medicine , thoracic aortic aneurysm , matrix metalloproteinase , collagenase , aortic aneurysm , extracellular matrix , interstitial collagenase , aneurysm , thoracic aorta , tissue inhibitor of metalloproteinase , pathology , aorta , cardiology , surgery , enzyme , biology , biochemistry

Thoracic aortic aneurysms (TAAs) develop secondary to abnormal aortic extracellular matrix remodeling, resulting in a weakened and dilated aortic wall that progressed to rupture if left unattended. Currently, no diagnostic/prognostic tests are available for the detection of TAA disease. This is largely driven by the lack of a large animal model, which would permit longitudinal/mechanistic studies. Accordingly, the objective of the present study was to establish a reproducible porcine model of aortic dilatation, which recapitulates the structural and biochemical changes observed during human TAA development.

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