Altered Apoptosis-Related Signaling After Cardioplegic Arrest in Patients With Uncontrolled Type 2 Diabetes Mellitus | Zendy

Jun Feng | Zendy; Yuhong Liu | Zendy; Nikola Dobrilovic | Zendy; Louis M. Chu | Zendy; Cesario Bianchi | Zendy; Arun Kumar Singh | Zendy; Frank W. Sellke | Zendy

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Altered Apoptosis-Related Signaling After Cardioplegic Arrest in Patients With Uncontrolled Type 2 Diabetes Mellitus

Author(s) -

Jun Feng,

Yuhong Liu,

Nikola Dobrilovic,

Louis M. Chu,

Cesario Bianchi,

Arun Kumar Singh,

Frank W. Sellke

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.000332

Subject(s) - medicine , apoptosis , terminal deoxynucleotidyl transferase , tunel assay , endocrinology , diabetes mellitus , protein kinase c , adenosine , poly adp ribose polymerase , kinase , immunohistochemistry , biology , polymerase , biochemistry , enzyme

We investigated the effects of cardioplegic arrest and reperfusion (CP/Rep) on myocardial apoptosis and key apoptotic mediators, such as apoptosis-inducing factor, caspase 3, caspase 8, caspase 9, poly(adenosine diphosphate-ribose) polymerase, B-cell lymphoma 2 (Bcl-2) family proteins, and protein kinase C (PKC), in uncontrolled type 2 diabetic, controlled type 2 diabetic, and nondiabetic patients.

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