Sevoflurane Preconditioning Attenuates Myocardial Ischemia/Reperfusion Injury via Caveolin-3–Dependent Cyclooxygenase-2 Inhibition | Zendy

Jianli Zhao | Zendy; Feng Wang | Zendy; Yanqing Zhang | Zendy; Liyuan Jiao | Zendy; Wayne Bond Lau | Zendy; Lili Wang | Zendy; Baojiang Liu | Zendy; Erhe Gao | Zendy; Walter J. Koch | Zendy; Xinliang Ma | Zendy; Yajing Wang | Zendy

Open Access

Sevoflurane Preconditioning Attenuates Myocardial Ischemia/Reperfusion Injury via Caveolin-3–Dependent Cyclooxygenase-2 Inhibition

Author(s) -

Jianli Zhao,

Feng Wang,

Yanqing Zhang,

Liyuan Jiao,

Wayne Bond Lau,

Lili Wang,

Baojiang Liu,

Erhe Gao,

Walter J. Koch,

Xinliang Ma,

Yajing Wang

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.112.000045

Subject(s) - cardioprotection , medicine , ampk , sevoflurane , caveolin 3 , reperfusion injury , cyclooxygenase , knockout mouse , ischemia , caveolin 1 , nicotinamide adenine dinucleotide phosphate , pharmacology , endocrinology , autophagy , protein kinase a , apoptosis , kinase , signal transduction , caveolae , oxidase test , chemistry , biochemistry , enzyme , receptor

The inhaled anesthetic sevoflurane has been demonstrated to protect against myocardial ischemia/reperfusion (MI/R) injury via mechanisms involving AMP-activated protein kinase (AMPK) and caveolin-3 (Cav-3). However, the relative contributions of AMPK and Cav-3 to sevoflurane preconditioning (SF-PreCon)-mediated cardioprotection and their precise underlying mechanisms of action remain incompletely understood.

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