Open AccessThymosin β4 Increases the Potency of Transplanted Mesenchymal Stem Cells for Myocardial Repair
Author(s) -
Lei Ye,
Pengyuan Zhang,
Sue Duval,
Liping Su,
Qiang Xiong,
Jianyi Zhang
Publication year - 2013
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.112.000025
Subject(s) - medicine , mesenchymal stem cell , potency , stem cell , transplantation , microbiology and biotechnology , in vitro , pathology , biochemistry , biology , chemistry
Thymosin β4 (Tβ4) has been shown to enhance the survival of cultured cardiomyocytes. Here, we investigated whether the cytoprotective effects of Tβ4 can increase the effectiveness of transplanted swine mesenchymal stem cells (sMSCs) for cardiac repair in a rat model of myocardial infarction (MI).
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