A Novel Regulator of Macrophage Activation | Zendy

Guoqing Zhuang | Zendy; Cong Meng | Zendy; Xin Guo | Zendy; Patali S. Cheruku | Zendy; Lei Shi | Zendy; Hang Xu | Zendy; Honggui Li | Zendy; Gang Wang | Zendy; Ashley R. Evans | Zendy; Stephen Safe | Zendy; Chaodong Wu | Zendy; Beiyan Zhou | Zendy

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A Novel Regulator of Macrophage Activation

Author(s) -

Guoqing Zhuang,

Cong Meng,

Xin Guo,

Patali S. Cheruku,

Lei Shi,

Hang Xu,

Honggui Li,

Gang Wang,

Ashley R. Evans,

Stephen Safe,

Chaodong Wu,

Beiyan Zhou

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.087817

Subject(s) - adipose tissue , macrophage polarization , proinflammatory cytokine , inflammation , adipose tissue macrophages , insulin resistance , regulator , macrophage , medicine , m2 macrophage , microbiology and biotechnology , immunology , endocrinology , biology , white adipose tissue , insulin , biochemistry , in vitro , gene

Macrophage activation plays a crucial role in regulating adipose tissue inflammation and is a major contributor to the pathogenesis of obesity-associated cardiovascular diseases. On various types of stimuli, macrophages respond with either classic (M1) or alternative (M2) activation. M1- and M2-mediated signaling pathways and corresponding cytokine production profiles are not completely understood. The discovery of microRNAs provides a new opportunity to understand this complicated but crucial network for macrophage activation and adipose tissue function.

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