Transplantation and Tracking of Human-Induced Pluripotent Stem Cells in a Pig Model of Myocardial Infarction
Author(s) -
Christian Templin,
Robert Zweigerdt,
Kristin Schwanke,
Ruth Olmer,
Jelena-Rima Ghadri,
Maximilian Y. Emmert,
E. Müller,
Silke Küest,
Susan Cohrs,
Roger Schibli,
Peter Kronen,
Monika Hilbe,
Andreas Reinisch,
Dirk Strunk,
Axel Haverich,
Simon P. Hoerstrup,
Thomas F. Lüscher,
Philipp A. Kaufmann,
Ulf Landmesser,
Ulrich Martin
Publication year - 2012
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.111.087684
Subject(s) - medicine , induced pluripotent stem cell , transplantation , stem cell , myocardial infarction , cardiology , infarction , embryonic stem cell , microbiology and biotechnology , gene , genetics , biology
Evaluation of novel cellular therapies in large-animal models and patients is currently hampered by the lack of imaging approaches that allow for long-term monitoring of viable transplanted cells. In this study, sodium iodide symporter (NIS) transgene imaging was evaluated as an approach to follow in vivo survival, engraftment, and distribution of human-induced pluripotent stem cell (hiPSC) derivatives in a pig model of myocardial infarction.
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