MicroRNA-145 Targeted Therapy Reduces Atherosclerosis | Zendy

Fina Lovren | Zendy; Yi Pan | Zendy; Adrian Quan | Zendy; Krishna K. Singh | Zendy; Praphulla Chandra Shukla | Zendy; Nandini Gupta | Zendy; Brent M. Steer | Zendy; Alistair J. Ingram | Zendy; Milan Gupta | Zendy; Mohammed AlOmran | Zendy; Hwee Teoh | Zendy; Philip A. Marsden | Zendy; Subodh Verma | Zendy

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MicroRNA-145 Targeted Therapy Reduces Atherosclerosis

Author(s) -

Fina Lovren,

Yi Pan,

Adrian Quan,

Krishna K. Singh,

Praphulla Chandra Shukla,

Nandini Gupta,

Brent M. Steer,

Alistair J. Ingram,

Milan Gupta,

Mohammed AlOmran,

Hwee Teoh,

Philip A. Marsden,

Subodh Verma

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.084186

Subject(s) - myocardin , calponin , microrna , vascular smooth muscle , klf4 , medicine , apolipoprotein e , fibrous cap , apolipoprotein b , pathology , cancer research , endocrinology , biology , gene expression , serum response factor , smooth muscle , cholesterol , embryonic stem cell , gene , biochemistry , disease , induced pluripotent stem cell

MicroRNA are essential posttranscriptional modulators of gene expression implicated in various chronic diseases. Because microRNA-145 is highly expressed in vascular smooth muscle cells (VSMC) and regulates VSMC fate and plasticity, we hypothesized that it may be a novel regulator of atherosclerosis and plaque stability.

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