Ca 2+ -Stimulated Adenylyl Cyclase AC1 Generates Efficient Biological Pacing as Single Gene Therapy and in Combination With HCN2 | Zendy

Gerard J.J. Boink | Zendy; Bruce D. Nearing | Zendy; Iry. Shlapakova | Zendy; Lian Duan | Zendy; Yelena Kryukova | Zendy; Yevgeniy Bobkov | Zendy; Hanno L. Tan | Zendy; Ira S. Cohen | Zendy; Peter Danilo | Zendy; Richard B. Robinson | Zendy; Richard L. Verrier | Zendy; Michael R. Rosen | Zendy

Open Access

Ca ²⁺ -Stimulated Adenylyl Cyclase AC1 Generates Efficient Biological Pacing as Single Gene Therapy and in Combination With HCN2

Author(s) -

Gerard J.J. Boink,

Bruce D. Nearing,

Iry. Shlapakova,

Lian Duan,

Yelena Kryukova,

Yevgeniy Bobkov,

Hanno L. Tan,

Ira S. Cohen,

Peter Danilo,

Richard B. Robinson,

Richard L. Verrier,

Michael R. Rosen

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.083584

Subject(s) - adenylyl cyclase , medicine , pharmacology , receptor

Biological pacing performed solely via HCN2 gene transfer in vivo results in relatively slow idioventricular rates and only moderate autonomic responsiveness. We induced biological pacing using the Ca(2+)-stimulated adenylyl cyclase AC1 gene expressed alone or in combination with HCN2 and compared outcomes with those with single-gene HCN2 transfer.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research