Experimental Abdominal Aortic Aneurysm Formation Is Mediated by IL-17 and Attenuated by Mesenchymal Stem Cell Treatment | Zendy

Ashish K. Sharma | Zendy; Guanyi Lu | Zendy; Andrea Jester | Zendy; William F. Johnston | Zendy; Yunge Zhao | Zendy; Vanessa A. Hajzus | Zendy; M. Reza Saadatzadeh | Zendy; Gang Su | Zendy; Castigliano M. Bhamidipati | Zendy; Gaurav Mehta | Zendy; Irving L. Kron | Zendy; Victor E. Laubach | Zendy; Michael P. Murphy | Zendy; Gorav Ailawadi | Zendy; Gilbert R. Upchurch | Zendy

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Experimental Abdominal Aortic Aneurysm Formation Is Mediated by IL-17 and Attenuated by Mesenchymal Stem Cell Treatment

Author(s) -

Ashish K. Sharma,

Guanyi Lu,

Andrea Jester,

William F. Johnston,

Yunge Zhao,

Vanessa A. Hajzus,

M. Reza Saadatzadeh,

Gang Su,

Castigliano M. Bhamidipati,

Gaurav Mehta,

Irving L. Kron,

Victor E. Laubach,

Michael P. Murphy,

Gorav Ailawadi,

Gilbert R. Upchurch

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.083451

Subject(s) - medicine , mesenchymal stem cell , abdominal aortic aneurysm , stem cell , aortic aneurysm , immunology , cardiology , surgery , pathology , aneurysm , aorta , microbiology and biotechnology , biology

Abdominal aortic aneurysm (AAA) formation is characterized by inflammation, smooth muscle activation and matrix degradation. This study tests the hypothesis that CD4+ T-cell-produced IL-17 modulates inflammation and smooth muscle cell activation, leading to the pathogenesis of AAA and that human mesenchymal stem cell (MSC) treatment can attenuate IL-17 production and AAA formation.

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