Myocardial CXCR4 Expression Is Required for Mesenchymal Stem Cell Mediated Repair Following Acute Myocardial Infarction | Zendy

Feng Dong | Zendy; James E. Harvey | Zendy; Amanda Finan | Zendy; Kristal Weber | Zendy; Udit Agarwal | Zendy; Marc S. Penn | Zendy

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Myocardial CXCR4 Expression Is Required for Mesenchymal Stem Cell Mediated Repair Following Acute Myocardial Infarction

Author(s) -

Feng Dong,

James E. Harvey,

Amanda Finan,

Kristal Weber,

Udit Agarwal,

Marc S. Penn

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.082453

Subject(s) - medicine , mesenchymal stem cell , myocardial infarction , progenitor cell , endothelial progenitor cell , ejection fraction , myocyte , cardiology , stem cell , heart failure , pathology , biology , microbiology and biotechnology

Overexpression of stromal cell-derived factor-1 in injured tissue leads to improved end-organ function. In this study, we quantify the local trophic effects of mesenchymal stem cell (MSC) stromal cell-derived factor-1 release on the effects of MSC engraftment in the myocardium after acute myocardial infarction.

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