The Evolution of Chemokine Release Supports a Bimodal Mechanism of Spinal Cord Ischemia and Reperfusion Injury | Zendy

Phillip D. Smith | Zendy; Ferenc Puskás | Zendy; Xianzhong Meng | Zendy; JoonHyung Lee | Zendy; Joseph C. Cleveland | Zendy; Michael J. Weyant | Zendy; David A. Fullerton | Zendy; T. Brett Reece | Zendy

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The Evolution of Chemokine Release Supports a Bimodal Mechanism of Spinal Cord Ischemia and Reperfusion Injury

Author(s) -

Phillip D. Smith,

Ferenc Puskás,

Xianzhong Meng,

JoonHyung Lee,

Joseph C. Cleveland,

Michael J. Weyant,

David A. Fullerton,

T. Brett Reece

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.080275

Subject(s) - medicine , mechanism (biology) , ischemia , spinal cord injury , chemokine , reperfusion injury , spinal cord , anesthesia , neuroscience , inflammation , cardiology , immunology , psychiatry , philosophy , epistemology , biology

Paraplegia remains a devastating complication of thoracic aortic surgery. The mechanism of the antecedent spinal cord ischemia and reperfusion injury (IR) remains poorly described. IR involves 2 injuries, an initial ischemic insult and subsequent inflammatory amplification of the injury. This mechanism is consistent with the clinical phenomenon of delayed onset paraplegia. This study sought to characterize the inflammatory response in the spinal cord after IR and hypothesized that this would support a bimodal mechanism of injury.

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