Open AccessRheb is a Critical Regulator of Autophagy During Myocardial Ischemia
Author(s) -
Sebastiano Sciarretta,
Peiyong Zhai,
Dan Shao,
Yasuhiro Maejima,
Jeffrey Robbins,
Massimo Volpe,
Gianluigi Condorelli,
Junichi Sadoshima
Publication year - 2012
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.111.078212
Subject(s) - rheb , mtorc1 , autophagy , medicine , microbiology and biotechnology , cancer research , pi3k/akt/mtor pathway , pharmacology , biology , apoptosis , signal transduction , biochemistry
Rheb is a GTP-binding protein that promotes cell survival and mediates the cellular response to energy deprivation (ED). The role of Rheb in the regulation of cell survival during ED has not been investigated in the heart.
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