The Angiogenic Factor Secretoneurin Induces Coronary Angiogenesis in a Model of Myocardial Infarction by Stimulation of Vascular Endothelial Growth Factor Signaling in Endothelial Cells | Zendy

Karin Albrecht-Schgoer | Zendy; Wilfried Schgoer | Zendy; Johannes Holfeld | Zendy; Markus Theurl | Zendy; Dominik Wiedemann | Zendy; Christina Steger | Zendy; Rajesh Gupta | Zendy; Severin Semsroth | Zendy; Reiner FischerColbrie | Zendy; Arno Beer | Zendy; Ursula Stanzl | Zendy; E. Huber | Zendy; Sol Misener | Zendy; Daniel Dejaco | Zendy; Raj Kishore | Zendy; Otmar Pachinger | Zendy; Michael Grimm | Zendy; Nikolaos Bonaros | Zendy; Rudolf Kirchmair | Zendy

Open Access

The Angiogenic Factor Secretoneurin Induces Coronary Angiogenesis in a Model of Myocardial Infarction by Stimulation of Vascular Endothelial Growth Factor Signaling in Endothelial Cells

Author(s) -

Karin Albrecht-Schgoer,

Wilfried Schgoer,

Johannes Holfeld,

Markus Theurl,

Dominik Wiedemann,

Christina Steger,

Rajesh Gupta,

Severin Semsroth,

Reiner FischerColbrie,

Arno Beer,

Ursula Stanzl,

E. Huber,

Sol Misener,

Daniel Dejaco,

Raj Kishore,

Otmar Pachinger,

Michael Grimm,

Nikolaos Bonaros,

Rudolf Kirchmair

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.076950

Subject(s) - medicine , angiogenesis , vascular endothelial growth factor , myocardial infarction , stimulation , vascular endothelial growth factor a , vascular endothelial growth factor b , endothelial stem cell , cardiology , cancer research , vegf receptors , biology , in vitro , biochemistry

Secretoneurin is a neuropeptide located in nerve fibers along blood vessels, is upregulated by hypoxia, and induces angiogenesis. We tested the hypothesis that secretoneurin gene therapy exerts beneficial effects in a rat model of myocardial infarction and evaluated the mechanism of action on coronary endothelial cells.

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