Paradoxical Effect of Increased Diastolic Ca 2+ Release and Decreased Sinoatrial Node Activity in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia | Zendy

Patricia Ñeco | Zendy; Angelo G. Torrente | Zendy; Pietro Mesirca | Zendy; Esther Zorio | Zendy; Nian Liu | Zendy; Silvia G. Priori | Zendy; Carlo Napolitano | Zendy; Sylvain Richard | Zendy; JeanPierre Bénitah | Zendy; Matteo E. Mangoni | Zendy; Ana M. Gómez | Zendy

Open Access

Paradoxical Effect of Increased Diastolic Ca ²⁺ Release and Decreased Sinoatrial Node Activity in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

Author(s) -

Patricia Ñeco,

Angelo G. Torrente,

Pietro Mesirca,

Esther Zorio,

Nian Liu,

Silvia G. Priori,

Carlo Napolitano,

Sylvain Richard,

JeanPierre Bénitah,

Matteo E. Mangoni,

Ana M. Gómez

Publication year - 2012

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.111.075382

Subject(s) - catecholaminergic polymorphic ventricular tachycardia , medicine , sinoatrial node , catecholaminergic , cardiology , tachycardia , diastole , diastolic depolarization , endocrinology , ryanodine receptor 2 , heart rate , catecholamine , calcium , blood pressure , ryanodine receptor

Catecholaminergic polymorphic ventricular tachycardia is characterized by stress-triggered syncope and sudden death. Patients with catecholaminergic polymorphic ventricular tachycardia manifest sinoatrial node (SAN) dysfunction, the mechanisms of which remain unexplored.

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